The Center for Community Health and Vitality (CCHV) and the South Side Health and Vitality Studies (SSHVS) define the South Side of Chicago as thirty-four of Chicago's 77 community areas on the SSHVS Area Map. The University of Chicago Medical Center serves these 34 communities and the more than one million people who live here.

The Center for Community Health and Vitality will be located in one of the communities surrounding the University. Although its location has not yet been finalized, its mission is already underway.

The South Side Health and Vitality Studies focus on health and wellness in the thirty-four community areas. One of the first efforts, the Asset Census Project, began in July 2009 by gathering information about resources such as businesses, non-profit organizations, and community organizations in East Side, Grand Boulevard, Hyde Park, Kenwood, Washington Park and Woodlawn.  Since 2009, over 5,000 organizations and businesses have been identified in 11 of the 34 South Side communities where the census has been completed.  Data gathered through this project is available to the public on SouthSideHealth.org.